A Study of 11-[(3)H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats

Tetrodotoxin (TTX) is a powerful sodium channel blocker that in low doses can safely relieve severe pain. Studying the absorption, distribution, metabolism and excretion (ADME) of TTX is challenging given the extremely low lethal dose. We conducted radiolabeled ADME studies in Sprague-Dawley rats. A...

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Publicado en:Mar Drugs
Main Authors: Hong, Bihong, Chen, Hui, Han, Jiacai, Xie, Quanling, He, Jianlin, Bai, Kaikai, Dong, Yanming, Yi, Ruizao
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484109/
https://ncbi.nlm.nih.gov/pubmed/28574462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15060159
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