A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague–Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite

Leucine is an essential branched-chain amino acid that acts as a substrate for protein synthesis and as a signaling molecule. Leucine not incorporated into muscle protein is ultimately oxidized through intermediates such as β-hydroxy-β-methylbutyrate (HMB) which itself is reported to enhance muscle...

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Bibliographic Details
Published in:Amino Acids
Main Authors: Lee, Anthony J., Beno, David W. A., Zhang, Xiaolin, Shapiro, Robin, Mason, Mark, Mason-Bright, Tanita, Surber, Bruce, Edens, Neilé K.
Format: Artigo
Language:Inglês
Published: Springer Vienna 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412734/
https://ncbi.nlm.nih.gov/pubmed/25618754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-015-1920-6
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