A Study of 11-[(3)H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats

Tetrodotoxin (TTX) is a powerful sodium channel blocker that in low doses can safely relieve severe pain. Studying the absorption, distribution, metabolism and excretion (ADME) of TTX is challenging given the extremely low lethal dose. We conducted radiolabeled ADME studies in Sprague-Dawley rats. A...

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Detaylı Bibliyografya
Yayımlandı:Mar Drugs
Asıl Yazarlar: Hong, Bihong, Chen, Hui, Han, Jiacai, Xie, Quanling, He, Jianlin, Bai, Kaikai, Dong, Yanming, Yi, Ruizao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484109/
https://ncbi.nlm.nih.gov/pubmed/28574462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15060159
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