Prospective comprehensive molecular characterization of lung adenocarcinomas for efficient patient matching to approved and emerging therapies

Tumor genetic testing is standard of care for patients with advanced lung adenocarcinoma but the fraction of patients who derive clinical benefit remains undefined. Here, we report the experience of 860 patients with metastatic lung adenocarcinoma analyzed prospectively for mutations in >300 canc...

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Pubblicato in:Cancer Discov
Autori principali: Jordan, Emmet J., Kim, Hyunjae R., Arcila, Maria E., Barron, David, Chakravarty, Debyani, Gao, JianJiong, Chang, Matthew T., Ni, Andy, Kundra, Ritika, Jonsson, Philip, Jayakumaran, Gowtham, Gao, Sizhi Paul, Johnsen, Hannah C., Hanrahan, Aphrothiti J., Zehir, Ahmet, Rekhtman, Natasha, Ginsberg, Michelle S., Li, Bob T., Yu, Helena A., Paik, Paul K., Drilon, Alexander, Hellmann, Matthew D., Reales, Dalicia N., Benayed, Ryma, Rusch, Valerie W., Kris, Mark G., Chaft, Jamie E., Baselga, Jose, Taylor, Barry S., Schultz, Nikolaus, Rudin, Charles M., Hyman, David M., Berger, Michael F., Solit, David B., Ladanyi, Marc, Riely, Gregory J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482929/
https://ncbi.nlm.nih.gov/pubmed/28336552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1337
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