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Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget

The various sphingosine kinase (SphK) isoenzymes (isozymes) and isoforms, key players in normal cellular physiology, are strongly implicated in cancer and other diseases. Mutations in SphKs, that may justify abnormal physiological function, have not been recorded. Nonetheless, there is a large and g...

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Опубликовано в: :Oncotarget
Главные авторы: Hatoum, Diana, Haddadi, Nahal, Lin, Yiguang, Nassif, Najah T., McGowan, Eileen M.
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482707/
https://ncbi.nlm.nih.gov/pubmed/28415564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16370
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