Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF may in addition radiosensitize tumor cells by targeting thioredoxin reductase (TrxR), a critical enzyme in the antioxida...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Wang, Hui, Bouzakoura, Soumaya, de Mey, Sven, Jiang, Heng, Law, Kalun, Dufait, Inès, Corbet, Cyril, Verovski, Valeri, Gevaert, Thierry, Feron, Olivier, Van den Berge, Dirk, Storme, Guy, De Ridder, Mark
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2017
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482612/
https://ncbi.nlm.nih.gov/pubmed/28415723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16113
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