Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF may in addition radiosensitize tumor cells by targeting thioredoxin reductase (TrxR), a critical enzyme in the antioxida...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Hui, Bouzakoura, Soumaya, de Mey, Sven, Jiang, Heng, Law, Kalun, Dufait, Inès, Corbet, Cyril, Verovski, Valeri, Gevaert, Thierry, Feron, Olivier, Van den Berge, Dirk, Storme, Guy, De Ridder, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482612/
https://ncbi.nlm.nih.gov/pubmed/28415723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16113
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