Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species

Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF may in addition radiosensitize tumor cells by targeting thioredoxin reductase (TrxR), a critical enzyme in the antioxida...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Wang, Hui, Bouzakoura, Soumaya, de Mey, Sven, Jiang, Heng, Law, Kalun, Dufait, Inès, Corbet, Cyril, Verovski, Valeri, Gevaert, Thierry, Feron, Olivier, Van den Berge, Dirk, Storme, Guy, De Ridder, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482612/
https://ncbi.nlm.nih.gov/pubmed/28415723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16113
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky