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Small molecule-mediated inhibition of β-2-microglobulin-based amyloid fibril formation

In dialysis patients, β-2 microglobulin (β2m) can aggregate and eventually form amyloid fibrils in a condition known as dialysis-related amyloidosis, which deleteriously affects joint and bone function. Recently, several small molecules have been identified as potential inhibitors of β2m amyloid for...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Marcinko, Tyler M., Dong, Jia, LeBlanc, Raquel, Daborowski, Kate V., Vachet, Richard W.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481568/
https://ncbi.nlm.nih.gov/pubmed/28468825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.774083
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