A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis

Amplification and/or activation of the c-Myc protooncogene is one of the leading genetic events along hepatocarcinogenesis. The oncogenic potential of c-Myc has been proven experimentally by the finding that its overexpression in the mouse liver triggers tumor formation. However, the molecular mecha...

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Gepubliceerd in:Hepatology
Hoofdauteurs: Liu, Pin, Ge, Mengmeng, Hu, Junjie, Li, Xiaolei, Che, Li, Sun, Kun, Cheng, Lili, Huang, Yuedong, Pilo, Maria G., Cigliano, Antonio, Pes, Giovanni M., Pascale, Rosa M., Brozzetti, Stefania, Vidili, Gianpaolo, Porcu, Alberto, Cossu, Antonio, Palmieri, Giuseppe, Sini, Maria C., Ribback, Silvia, Dombrowski, Frank, Tao, Junyan, Calvisi, Diego F., Chen, Ligong, Chen, Xin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481473/
https://ncbi.nlm.nih.gov/pubmed/28370287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29183
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