Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy

The Kelch-like ECH-associating protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway is the major regulator of cytoprotective responses to oxidative and electrophilic stress. The Cul3/Keap1 E3 ubiquitin ligase complex interacts with...

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Publicado no:Sci Rep
Main Authors: Yoshizaki, Yuki, Mori, Takayasu, Ishigami-Yuasa, Mari, Kikuchi, Eriko, Takahashi, Daiei, Zeniya, Moko, Nomura, Naohiro, Mori, Yutaro, Araki, Yuya, Ando, Fumiaki, Mandai, Shintaro, Kasagi, Yuri, Arai, Yohei, Sasaki, Emi, Yoshida, Sayaka, Kagechika, Hiroyuki, Rai, Tatemitsu, Uchida, Shinichi, Sohara, Eisei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479848/
https://ncbi.nlm.nih.gov/pubmed/28638054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04233-3
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