Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters

Upon activation by with-no-lysine kinases, STE20/SPS1-related proline–alanine-rich protein kinase (SPAK) phosphorylates and activates SLC12A transporters such as the Na(+)-Cl(−) cotransporter (NCC) and Na(+)-K(+)-2Cl(−) cotransporter type 1 (NKCC1) and type 2 (NKCC2); these transporters have importa...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Kikuchi, Eriko, Mori, Takayasu, Zeniya, Moko, Isobe, Kiyoshi, Ishigami-Yuasa, Mari, Fujii, Shinya, Kagechika, Hiroyuki, Ishihara, Tomoaki, Mizushima, Tohru, Sasaki, Sei, Sohara, Eisei, Rai, Tatemitsu, Uchida, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2015
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483590/
https://ncbi.nlm.nih.gov/pubmed/25377078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014060560
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