A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

Mutations in WNK1 and WNK4 kinase genes have been shown to cause a human hereditary hypertensive disease, pseudohypoaldosteronism type II (PHAII). We previously discovered that WNK kinases phosphorylate and activate OSR1/SPAK kinases that regulate renal SLC12A family transporters such as NKCC2 and N...

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Bibliografiske detaljer
Main Authors: Oi, Katsuyuki, Sohara, Eisei, Rai, Tatemitsu, Misawa, Moko, Chiga, Motoko, Alessi, Dario R., Sasaki, Sei, Uchida, Shinichi
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507202/
https://ncbi.nlm.nih.gov/pubmed/23213404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.2011048
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