Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

Mutations in the WNK4 gene cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder of hyperkalemia and hypertension. The target molecules of this putative kinase and the molecular mechanisms by which the mutations cause the phenotypes are currently unknown. Although recent repo...

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Detalhes bibliográficos
Main Authors: Yamauchi, Kozue, Rai, Tatemitsu, Kobayashi, Katsuki, Sohara, Eisei, Suzuki, Tatsunori, Itoh, Tomohiro, Suda, Shin, Hayama, Atsushi, Sasaki, Sei, Uchida, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC384808/
https://ncbi.nlm.nih.gov/pubmed/15070779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306924101
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