PI3K/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

Metabolic syndrome patients have insulin resistance, which causes hyperinsulinemia, which in turn causes aberrant increased renal sodium reabsorption. The precise mechanisms underlying this greater salt-sensitivity of hyperinsulinemic patients remain unclear. Abnormal activation of the recently-iden...

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Bibliographic Details
Main Authors: Nishida, Hidenori, Sohara, Eisei, Nomura, Naohiro, Chiga, Motoko, Alessi, Dario R, Rai, Tatemitsu, Sasaki, Sei, Uchida, Shinichi
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743028/
https://ncbi.nlm.nih.gov/pubmed/22949526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.201509
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