Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene

Pseudohypoaldosteronism type II (PHAII) is a hereditary hypertensive disease caused by mutations in four different genes: with-no-lysine kinases (WNK) 1 and 4, Kelch-like family member 3 (KLHL3), and cullin 3 (Cul3). Cul3 and KLHL3 form an E3 ligase complex that ubiquitinates and reduces the express...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Araki, Yuya, Rai, Tatemitsu, Sohara, Eisei, Mori, Takayasu, Inoue, Yuichi, Isobe, Kiyoshi, Kikuchi, Eriko, Ohta, Akihito, Sasaki, Sei, Uchida, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728349/
https://ncbi.nlm.nih.gov/pubmed/26490675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.013276
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