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KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3

Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, kelch-like 3 (KLHL3), and cullin3 (CUL3) genes are known to cause the hereditary disease pseudohypoaldosteronism type II (PHAII). It was recently demonstrated that this results from the defective degradation of WNK1 and WNK4 by the KLHL3/CUL3 ub...

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Bibliografski detalji
Izdano u:Mol Cell Biol
Glavni autori: Sasaki, Emi, Susa, Koichiro, Mori, Takayasu, Isobe, Kiyoshi, Araki, Yuya, Inoue, Yuichi, Yoshizaki, Yuki, Ando, Fumiaki, Mori, Yutaro, Mandai, Shintaro, Zeniya, Moko, Takahashi, Daiei, Nomura, Naohiro, Rai, Tatemitsu, Uchida, Shinichi, Sohara, Eisei
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359427/
https://ncbi.nlm.nih.gov/pubmed/28052936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00508-16
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