Synergistic interactions with PI3K inhibition that induce apoptosis

Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K muta...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Zwang, Yaara, Jonas, Oliver, Chen, Casandra, Rinne, Mikael L, Doench, John G, Piccioni, Federica, Tan, Li, Huang, Hai-Tsang, Wang, Jinhua, Ham, Young Jin, O'Connell, Joyce, Bhola, Patrick, Doshi, Mihir, Whitman, Matthew, Cima, Michael, Letai, Anthony, Root, David E, Langer, Robert S, Gray, Nathanael, Hahn, William C
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479695/
https://ncbi.nlm.nih.gov/pubmed/28561737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24523
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