ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition

Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome scale CRISPR-Cas9 loss-of-function screens in two KRAS-mutant pancreati...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wang, Belinda, Krall, Elsa Beyer, Aguirre, Andrew James, Kim, Miju, Widlund, Hans Ragnar, Doshi, Mihir Bhavik, Sicinska, Ewa, Sulahian, Rita, Goodale, Amy, Cowley, Glenn Spencer, Piccioni, Federica, Doench, John Gerard, Root, David Edward, Hahn, William Chun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313047/
https://ncbi.nlm.nih.gov/pubmed/28178529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.031
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