Atxn1 protein family and Cic regulate extracellular matrix remodeling and lung alveolarization

Although expansion of CAG repeats in ATAXIN1 (ATXN1) causes Spinocerebellar ataxia type 1, the functions of ATXN1 and ATAXIN1-Like (ATXN1L) remain poorly understood. To investigate the function of these proteins, we generated and characterized Atxn1L(−/−) and Atxn1(−/−); Atxn1L(−/−) mice. Atxn1L(−/−...

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Autors principals: Lee, Yoontae, Fryer, John D., Kang, Hyojin, Crespo-Barreto, Juan, Bowman, Aaron B., Gao, Yan, Kahle, Juliette J., Hong, Jeong Soo, Kheradmand, Farrah, Orr, Harry T., Finegold, Milton J., Zoghbi, Huda Y.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253850/
https://ncbi.nlm.nih.gov/pubmed/22014525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.08.017
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