Nucleotide Excision Repair Lesion-Recognition Protein Rad4 Captures a Pre-Flipped Partner Base in a Benzo[a]pyrene-Derived DNA Lesion: How Structure Impacts the Binding Pathway

[Image: see text] [Image: see text] The xeroderma pigmentosum C protein complex (XPC) recognizes a variety of environmentally induced DNA lesions and is the key in initiating their repair by the nucleotide excision repair (NER) pathway. When bound to a lesion, XPC flips two nucleotide pairs that inc...

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Vydáno v:Chem Res Toxicol
Hlavní autoři: Mu, Hong, Geacintov, Nicholas E., Min, Jung-Hyun, Zhang, Yingkai, Broyde, Suse
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2017
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478902/
https://ncbi.nlm.nih.gov/pubmed/28460163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00074
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