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Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase

The genetic code is established in aminoacylation reactions catalyzed by aminoacyl-tRNA synthetases. Many aminoacyl-tRNA synthetases require an additional domain for editing, to correct errors made by the catalytic domain. A nonfunctional editing domain results in an ambiguous genetic code, where a...

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Autori principali: Bacher, Jamie M., de Crécy-Lagard, Valérie, Schimmel, Paul R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC547871/
https://ncbi.nlm.nih.gov/pubmed/15647356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409064102
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