p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish

Brain and heart pathologies are caused by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity by removing incorrect amino acids misattached to tRNAs. To extend understanding of the broader impact of synthetase editing reactions on organismal homeostasis, and base...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Song, Youngzee, Shi, Yi, Carland, Tristan M., Lian, Shanshan, Sasaki, Tomoyuki, Schork, Nicholas J., Head, Steven R., Kishi, Shuji, Schimmel, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968768/
https://ncbi.nlm.nih.gov/pubmed/27402763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608139113
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