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p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish

Brain and heart pathologies are caused by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity by removing incorrect amino acids misattached to tRNAs. To extend understanding of the broader impact of synthetase editing reactions on organismal homeostasis, and base...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Song, Youngzee, Shi, Yi, Carland, Tristan M., Lian, Shanshan, Sasaki, Tomoyuki, Schork, Nicholas J., Head, Steven R., Kishi, Shuji, Schimmel, Paul
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968768/
https://ncbi.nlm.nih.gov/pubmed/27402763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608139113
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