p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish

Brain and heart pathologies are caused by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity by removing incorrect amino acids misattached to tRNAs. To extend understanding of the broader impact of synthetase editing reactions on organismal homeostasis, and base...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Song, Youngzee, Shi, Yi, Carland, Tristan M., Lian, Shanshan, Sasaki, Tomoyuki, Schork, Nicholas J., Head, Steven R., Kishi, Shuji, Schimmel, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968768/
https://ncbi.nlm.nih.gov/pubmed/27402763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608139113
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