Identification and preliminary characterization of protein-cysteine farnesyltransferase.

Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to exert their biological activity. Previous studies indicate that an intermediate in the mevalonate pathway, most likely farnesyl pyrophosphate, is the dono...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Manne, V, Roberts, D, Tobin, A, O'Rourke, E, De Virgilio, M, Meyers, C, Ahmed, N, Kurz, B, Resh, M, Kung, H F
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1990
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2217184/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.19.7541
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