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Identification and preliminary characterization of protein-cysteine farnesyltransferase.

Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to exert their biological activity. Previous studies indicate that an intermediate in the mevalonate pathway, most likely farnesyl pyrophosphate, is the dono...

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Detalhes bibliográficos
Main Authors: Manne, V, Roberts, D, Tobin, A, O'Rourke, E, De Virgilio, M, Meyers, C, Ahmed, N, Kurz, B, Resh, M, Kung, H F
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC54783/
https://ncbi.nlm.nih.gov/pubmed/2217184
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