Serotonin Signaling Through the 5-HT(1B) Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension

OBJECTIVE—: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesize that in PASMCs, serotonin induces oxidative stress through NADPH-oxidase–deriv...

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Bibliographic Details
Published in:Arterioscler Thromb Vasc Biol
Main Authors: Hood, Katie Y., Mair, Kirsty M., Harvey, Adam P., Montezano, Augusto C., Touyz, Rhian M., MacLean, Margaret R.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2017
Subjects:
Basic Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478178/
https://ncbi.nlm.nih.gov/pubmed/28473438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308929
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