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Serotonin Signaling Through the 5-HT(1B) Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension

OBJECTIVE—: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesize that in PASMCs, serotonin induces oxidative stress through NADPH-oxidase–deriv...

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Bibliografiske detaljer
Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Hood, Katie Y., Mair, Kirsty M., Harvey, Adam P., Montezano, Augusto C., Touyz, Rhian M., MacLean, Margaret R.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5478178/
https://ncbi.nlm.nih.gov/pubmed/28473438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308929
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