The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1

Abstract. Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT(+)) in mice results in an estrogen-dependent development of pulmonary...

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Detalhes bibliográficos
Publicado no:Pulm Circ
Main Authors: Johansen, Anne Katrine Z., Dean, Afshan, Morecroft, Ian, Hood, Katie, Nilsen, Margaret, Loughlin, Lynn, Anagnostopoulou, Aikaterini, Touyz, Rhian M., White, Kevin, MacLean, Margaret R.
Formato: Artigo
Idioma:Inglês
Publicado em: University of Chicago Press 2016
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860551/
https://ncbi.nlm.nih.gov/pubmed/27162617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/685023
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