Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

AIMS: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. D...

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Autors principals: Dempsie, Yvonne, MacRitchie, Neil A., White, Kevin, Morecroft, Ian, Wright, Audrey F., Nilsen, Margaret, Loughlin, Lynn, Mair, Kirsty M., MacLean, Margaret R.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687748/
https://ncbi.nlm.nih.gov/pubmed/23519266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt064
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