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Gating of acetylcholine receptor channels: Brownian motion across a broad transition state
Acetylcholine receptor channels (AChRs) are proteins that switch between stable “closed” and “open” conformations. In patch clamp recordings, diliganded AChR gating appears to be a simple, two-state reaction. However, mutagenesis studies indicate that during gating dozens of residues across the prot...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC547815/ https://ncbi.nlm.nih.gov/pubmed/15665102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406787102 |
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