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Unliganded gating of acetylcholine receptor channels

We estimated the unliganded opening and closing rate constants of neuromuscular acetylcholine receptor-channels (AChRs) having mutations that increased the gating equilibrium constant. For some mutant combinations, spontaneous openings occurred in clusters. For 25 different constructs, the unligande...

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Hlavní autoři: Purohit, Prasad, Auerbach, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629231/
https://ncbi.nlm.nih.gov/pubmed/19114650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809272106
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