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Loop C and the mechanism of acetylcholine receptor–channel gating

Agonist molecules at the two neuromuscular acetylcholine (ACh) receptor (AChR) transmitter-binding sites increase the probability of channel opening. In one hypothesis for AChR activation (“priming”), the capping of loop C at each binding site transfers energy independently to the distant gate over...

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Autors principals: Purohit, Prasad, Auerbach, Anthony
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607824/
https://ncbi.nlm.nih.gov/pubmed/23478996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210946
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