Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

BACKGROUND: Natural IgM antibodies (Abs) function as innate immune sensors of injury via recognition of neoepitopes expressed on damaged cells, although how this recognition systems function following spinal cord injury (SCI) exposes various neoepitopes and their precise nature remains largely unkno...

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Detalles Bibliográficos
Publicado en:J Neuroinflammation
Main Authors: Narang, Aarti, Qiao, Fei, Atkinson, Carl, Zhu, Hong, Yang, Xiaofeng, Kulik, Liudmila, Holers, V. Michael, Tomlinson, Stephen
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477255/
https://ncbi.nlm.nih.gov/pubmed/28629465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0894-6
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