Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

PURPOSE: While multikinase inhibitors with RET activity are active in RET-rearranged thyroid and lung cancers, objective response rates are relatively low and toxicity can be substantial. The development of novel RET inhibitors with improved potency and/or reduced toxicity is thus an unmet need. RXD...

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Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Li, Gang G., Somwar, Romel, Joseph, James, Smith, Roger S., Hayashi, Takuo, Martin, Leenus, Franovic, Aleksandra, Schairer, Anni, Martin, Eric, Riely, Gregory J., Harris, Jason, Yan, Shunqi, Wei, Ge, Oliver, Jennifer W., Patel, Rupal, Multani, Pratik, Ladanyi, Marc, Drilon, Alexander
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477238/
https://ncbi.nlm.nih.gov/pubmed/28011461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1887
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