Human cancers converge at the HIF-2α oncogenic axis

Por Franovic, Aleksandra, Holterman, Chet E., Payette, Josianne, Lee, Stephen
Publicado em 2009

Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer

Por Franovic, Aleksandra, Gunaratnam, Lakshman, Smith, Karlene, Robert, Isabelle, Patten, David, Lee, Stephen
Publicado em 2007

DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia

Por Lachance, Gabriel, Uniacke, James, Audas, Timothy E., Holterman, Chet E., Franovic, Aleksandra, Payette, Josianne, Lee, Stephen
Publicado em 2014

Glioblastomas require integrin αvβ3/PAK4 signaling to escape senescence

Por Franovic, Aleksandra, Elliott, Kathryn C., Seguin, Laetitia, Camargo, M. Fernanda, Weis, Sara M., Cheresh, David A.
Publicado no Cancer Res (2015)

Integrin αvβ3 Drives Slug Activation and Stemness in the Pregnant and Neoplastic Mammary Gland

Por Desgrosellier, Jay S, Lesperance, Jacqueline, Seguin, Laetitia, Gozo, Maricel, Kato, Shumei, Franovic, Aleksandra, Yebra, Mayra, Shattil, Sanford J, Cheresh, David A
Publicado em 2014

An oxygen-regulated switch in the protein synthesis machinery

Por Uniacke, James, Holterman, Chet E., Lachance, Gabriel, Franovic, Aleksandra, Jacob, Mathieu D., Fabian, Marc R., Payette, Josianne, Holcik, Martin, Pause, Arnim, Lee, Stephen
Publicado no Nature (2012)

A MEK-independent role for CRAF in mitosis and tumor progression

Por Mielgo, Ainhoa, Seguin, Laetitia, Huang, Miller, Camargo, Maria Fernanda, Anand, Sudarshan, Franovic, Aleksandra, Weis, Sara M., Advani, Sunil J., Murphy, Eric A., Cheresh, David A.
Publicado em 2011

Kinase-independent role for CRAF-driving tumour radioresistance via CHK2

Por Advani, Sunil J., Camargo, Maria Fernanda, Seguin, Laetitia, Mielgo, Ainhoa, Anand, Sudarshan, Hicks, Angel M., Aguilera, Joseph, Franovic, Aleksandra, Weis, Sara M., Cheresh, David A.
Publicado no Nat Commun (2015)

Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

Por Li, Gang G., Somwar, Romel, Joseph, James, Smith, Roger S., Hayashi, Takuo, Martin, Leenus, Franovic, Aleksandra, Schairer, Anni, Martin, Eric, Riely, Gregory J., Harris, Jason, Yan, Shunqi, Wei, Ge, Oliver, Jennifer W., Patel, Rupal, Multani, Pratik, Ladanyi, Marc, Drilon, Alexander
Publicado no Clin Cancer Res (2016)

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

Por Wilson, RaeAnna, Espinosa-Diez, Cristina, Kanner, Nathan, Chatterjee, Namita, Ruhl, Rebecca, Hipfinger, Christina, Advani, Sunil J., Li, Jie, Khan, Omar F., Franovic, Aleksandra, Weis, Sara M., Kumar, Sushil, Coussens, Lisa M., Anderson, Daniel G., Chen, Clark C., Cheresh, David A., Anand, Sudarshan
Publicado no Nat Commun (2016)

A β3 integrin-KRAS-RalB complex drives tumor stemness and resistance to EGFR inhibition

Por Seguin, Laetitia, Kato, Shumei, Franovic, Aleksandra, Camargo, M. Fernanda, Lesperance, Jacqueline, Elliott, Kathryn C., Yebra, Mayra, Mielgo, Ainhoa, Lowy, Andrew M., Husain, Hatim, Cascone, Tina, Diao, Lixia, Wang, Jing, Wistuba, Ignacio I., Heymach, John V., Lippman, Scott M., Desgrosellier, Jay S., Anand, Sudarshan, Weis, Sara M., Cheresh, David A.
Publicado em 2014