Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

PURPOSE: While multikinase inhibitors with RET activity are active in RET-rearranged thyroid and lung cancers, objective response rates are relatively low and toxicity can be substantial. The development of novel RET inhibitors with improved potency and/or reduced toxicity is thus an unmet need. RXD...

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Publicado no:Clin Cancer Res
Main Authors: Li, Gang G., Somwar, Romel, Joseph, James, Smith, Roger S., Hayashi, Takuo, Martin, Leenus, Franovic, Aleksandra, Schairer, Anni, Martin, Eric, Riely, Gregory J., Harris, Jason, Yan, Shunqi, Wei, Ge, Oliver, Jennifer W., Patel, Rupal, Multani, Pratik, Ladanyi, Marc, Drilon, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477238/
https://ncbi.nlm.nih.gov/pubmed/28011461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1887
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