A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105

RET fusions are oncogenic drivers of various tumors, including non-small cell lung cancers (NSCLCs). The safety and antitumor activity of the multikinase RET inhibitor RXDX-105 were explored in a phase I/Ib trial. A recommended phase 2 dose of 275 mg fed daily was identified. The most common treatme...

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Udgivet i:Cancer Discov
Main Authors: Drilon, Alexander, Fu, Siqing, Patel, Manish R., Fakih, Marwan, Wang, Ding, Olszanski, Anthony J., Morgensztern, Daniel, Liu, Stephen V., Cho, Byoung Chul, Bazhenova, Lyudmila, Rodriguez, Cristina P., Doebele, Robert C., Wozniak, Antoinette, Reckamp, Karen L., Seery, Tara, Nikolinakos, Petros, Hu, Zheyi, Oliver, Jennifer W., Trone, Denise, McArthur, Katherine, Patel, Rupal, Multani, Pratik S., Ahn, Myung-Ju
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397691/
https://ncbi.nlm.nih.gov/pubmed/30487236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0839
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