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MEDU-39. YAP1 IS NECESSARY FOR TUMORIGENESIS AND CANCER STEM CELL MAINTENANCE IN SHH-INDUCED MEDULLOBLASTOMAS
Treatments with minimal adverse effects are particularly important for pediatric brain tumor patients to preserve normal brain development and function. We propose that SHH medulloblastomas may be safely treated with a YAP1 inhibitor. YAP1, a transcriptional effector of the Hippo signaling pathway,...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5475163/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.189 |
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