MEDU-39. YAP1 IS NECESSARY FOR TUMORIGENESIS AND CANCER STEM CELL MAINTENANCE IN SHH-INDUCED MEDULLOBLASTOMAS

Treatments with minimal adverse effects are particularly important for pediatric brain tumor patients to preserve normal brain development and function. We propose that SHH medulloblastomas may be safely treated with a YAP1 inhibitor. YAP1, a transcriptional effector of the Hippo signaling pathway,...

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Udgivet i:Neuro Oncol
Main Authors: Natarajan, Sivaraman, George, Joshy, Camargo, Fernando, Yun, Kyuson
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475163/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.189
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