PDTM-11. YAP1 IS NECESSARY FOR TUMORIGENESIS AND CANCER STEM CELLMAINTENANCE IN SHH-INDUCED MEDULLOBLASTOMAS

Anti-cancer treatments with minimal adverse effects are particularly important for pediatric brain tumor patients to preserve normal brain development and function. We propose that SHH medulloblastomas may be safely treated with a YAP1 inhibitor. YAP1, a transcriptional effector of the Hippo signali...

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Vydáno v:Neuro Oncol
Hlavní autoři: Natarajan, Sivaraman, George, Joshy, Olson, James M, Camargo, Fernando, Yun, Kyuson
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692271/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.776
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