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PDTM-11. YAP1 IS NECESSARY FOR TUMORIGENESIS AND CANCER STEM CELLMAINTENANCE IN SHH-INDUCED MEDULLOBLASTOMAS

Anti-cancer treatments with minimal adverse effects are particularly important for pediatric brain tumor patients to preserve normal brain development and function. We propose that SHH medulloblastomas may be safely treated with a YAP1 inhibitor. YAP1, a transcriptional effector of the Hippo signali...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Natarajan, Sivaraman, George, Joshy, Olson, James M, Camargo, Fernando, Yun, Kyuson
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692271/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.776
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