ATRT-07. AN EPIGENOME DIRECTED FUNCTIONAL GENOMIC SCREEN IDENTIFIES SIRT2 AS A SYNTHETIC LETHAL TARGET IN SMARCB1 DEFICIENT ATRT

Atypical Teratoid Rhabdoid Tumor (ATRT) is a highly aggressive pediatric brain tumor with poor outcomes. Therapy relies on highly toxic chemotherapy and radiotherapy. The central mechanism of ATRT tumorigenesis is SMARCB1 deficiency that leads to epigenetic dysregulation. To identify key epigenetic...

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Publicado no:Neuro Oncol
Main Authors: Alimova, Irina, Venkataraman, Sujatha, Balakrishnan, Ilango, Pierce, Angela M, Mulcahy-Levy, Jean, Foreman, Nicholas K, Vibhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474971/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.006
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