ATRT-07. AN EPIGENOME DIRECTED FUNCTIONAL GENOMIC SCREEN IDENTIFIES SIRT2 AS A SYNTHETIC LETHAL TARGET IN SMARCB1 DEFICIENT ATRT

Atypical Teratoid Rhabdoid Tumor (ATRT) is a highly aggressive pediatric brain tumor with poor outcomes. Therapy relies on highly toxic chemotherapy and radiotherapy. The central mechanism of ATRT tumorigenesis is SMARCB1 deficiency that leads to epigenetic dysregulation. To identify key epigenetic...

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Publicat a:Neuro Oncol
Autors principals: Alimova, Irina, Venkataraman, Sujatha, Balakrishnan, Ilango, Pierce, Angela M, Mulcahy-Levy, Jean, Foreman, Nicholas K, Vibhakar, Rajeev
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474971/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.006
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