Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding

Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-binding protein (PABP) that circularizes mRNAs, promoting translation and stab...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Smith, Richard W. P., Anderson, Ross C., Larralde, Osmany, Smith, Joel W. S., Gorgoni, Barbara, Richardson, William A., Malik, Poonam, Graham, Sheila V., Gray, Nicola K.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474791/
https://ncbi.nlm.nih.gov/pubmed/28559344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610417114
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