Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding

Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-binding protein (PABP) that circularizes mRNAs, promoting translation and stab...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Smith, Richard W. P., Anderson, Ross C., Larralde, Osmany, Smith, Joel W. S., Gorgoni, Barbara, Richardson, William A., Malik, Poonam, Graham, Sheila V., Gray, Nicola K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474791/
https://ncbi.nlm.nih.gov/pubmed/28559344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610417114
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi