A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

Oxidative phosphorylation (OXPHOS) is the major pathway for ATP production in humans. Deficiencies in OXPHOS can arise from mutations in either mitochondrial or nuclear genomes and comprise the largest collection of inborn errors of metabolism. At present we lack a complete catalog of human genes an...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Metab
Main Authors: Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474757/
https://ncbi.nlm.nih.gov/pubmed/27667664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.08.017
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