A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

Oxidative phosphorylation (OXPHOS) is the major pathway for ATP production in humans. Deficiencies in OXPHOS can arise from mutations in either mitochondrial or nuclear genomes and comprise the largest collection of inborn errors of metabolism. At present we lack a complete catalog of human genes an...

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Bibliografiska uppgifter
I publikationen:Cell Metab
Huvudupphovsmän: Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474757/
https://ncbi.nlm.nih.gov/pubmed/27667664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.08.017
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