Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

G-quadruplex (G4) is a higher-order nucleic acid structure that is formed by guanine-rich sequences. G4 stabilization by small-molecule compounds called G4 ligands often causes cytotoxicity, although the potential medicinal impact of this effect has not been fully established. Here we demonstrate th...

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Pubblicato in:Sci Rep
Autori principali: Nakamura, Takahiro, Okabe, Sachiko, Yoshida, Haruka, Iida, Keisuke, Ma, Yue, Sasaki, Shogo, Yamori, Takao, Shin-ya, Kazuo, Nakano, Ichiro, Nagasawa, Kazuo, Seimiya, Hiroyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472576/
https://ncbi.nlm.nih.gov/pubmed/28620243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03785-8
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