Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

Macrocyclic hexaoxazole dimer of L2H2-6OTD-dimer (3) was newly synthesized as a telomeric G-quadruplex (G4) ligand, and interaction with long telomeric DNAs telo48, 72, and 96 was evaluated by means of electrophoresis mobility shift assay, CD spectra analysis, and CD melting experiments. The L2H2-6O...

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Gepubliceerd in:Molecules
Hoofdauteurs: Iida, Keisuke, Majima, Satoki, Nakamura, Takahiro, Seimiya, Hiroyuki, Nagasawa, Kazuo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269967/
https://ncbi.nlm.nih.gov/pubmed/23584054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18044328
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