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Evaluation of the Interaction between Long Telomeric DNA and Macrocyclic Hexaoxazole (6OTD) Dimer of a G-quadruplex Ligand

Macrocyclic hexaoxazole dimer of L2H2-6OTD-dimer (3) was newly synthesized as a telomeric G-quadruplex (G4) ligand, and interaction with long telomeric DNAs telo48, 72, and 96 was evaluated by means of electrophoresis mobility shift assay, CD spectra analysis, and CD melting experiments. The L2H2-6O...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Iida, Keisuke, Majima, Satoki, Nakamura, Takahiro, Seimiya, Hiroyuki, Nagasawa, Kazuo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269967/
https://ncbi.nlm.nih.gov/pubmed/23584054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18044328
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